Alabama Neuroscience Blueprint Core Center

 

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Core E - In Vivo Physiology & Phenotyping

The In Vivo Physiology & Phenotyping Core provides services to characterize several aspects of homeostatic physiology in mouse lines.  Specifically, we monitor the physiology and behavior of mice in home cage environments in group or individual settings, using telemetry to assess arterial pressure, heart rate, activity, body temperature, EEG activity, feeding and drinking and social interactions.  Most monitoring will allow for simultaneous, 24-hour, remote assessment of these characteristics in up to 8 interacting animals.  Depending on the level of interest, in subsequent years we may provide a cerebral blood flow protocol in the Core.  The other focus of the Core is on in vivo quantification of metabolism and body composition in transgenic/knockout mice.  Metabolic rate, via indirect calorimetry (oxygen consumption and carbon dioxide production) is assessed in mice over a period of hours or days, depending on the research questions of the NIH Blueprint investigator.  Activity and food intake is simultaneously measured in the mice, and body composition (fat, lean, and bone) is assessed in vivo using dual-energy X-ray absorptiometry, quantitative magnetic resonance and other allied methods. 

Core E provides:

         

  • Indirect blood pressure and heart rate measurements (tail cuff) in mice.
  • Direct (Tethered) blood pressure and heart rate measurements in mice.
  • Telemetric blood pressure and heart rate and activity measures in mice. 
  • Telemetric EEG recording in mice.
  • Learning tasks in mice.
  • IntelliCage testing of learning and memory in mice, in a social environment.
  • Metabolic rate measurements in mice and rats.
  • Activity and food intake measurements in mice and rats.
  • Body composition measurements in mice and rats.

 

Neuroscience Core Day Presentation

 

Note: When appropriate, please acknowledge the use of the Alabama Neuroscience Blueprint Core Center: "This work was supported by NIH Neuroscience Blueprint Core Grant NS57098 to the University of Alabama at Birmingham."

  Core E Pic

                 Director:         J. Michael Wyss, Ph.D.

           Co-Directors:         Timothy Nagy, Ph.D.

 

 

Contact Information:

 

Maria Johnson, PhD.
Research Associate
1530 Third Avenue S; WEBB 433
Birmingham, AL 35294-3361
Phone: (205)934-4008
Fax: (205) 934-7050
E-mail: mariajoh@uab.edu